The achievement of a good water quality in all water bodies until 2015 is legally regulated since December 2000 for all European Union member states by the European Water Framework Directive (EU, 2000). The aim of this project is to detect nutrient entry pathways and to assess the dominating hydrological processes in complex mesoscale catchments. The investigated Treene catchment is located in Northern Germany as a part of a lowland area. Sandy, loamy and peat soils are characteristic for this area. Land use is dominated by agriculture and pasture. Drainage changed the natural water balance. In a nested approach we examined two catchment areas: a) Treene catchment 517 km 2 , b) Kielstau catchment 50 km 2 . The nested approach assists to improve the process understanding by using data of different scales. Therefore these catchments serve not only as an example but the results are transferable to other lowland catchment areas. In a first step the river basin scale model SWAT (Soil and Water Assessment Tool, Arnold et al., 1998) was used successfully to model the water balance. Furthermore the water quality was analysed to distinguish the impact of point and diffuse sources. The results show that the tributaries in the Kielstau catchment contribute high amounts of nutrients, mainly nitrate and ammonium. For the parameters nitrate, ammonium and phosphorus it was observed as a tendency that the annual loads were increasing along the river profile of the Kielstau.
International audience ; The achievement of a good water quality in all water bodies until 2015 is legally regulated since December 2000 for all European Union member states by the European Water Framework Directive (EU, 2000). The aim of this project is to detect nutrient entry pathways and to assess the dominating hydrological processes in complex mesoscale catchments. The investigated Treene catchment is located in Northern Germany as a part of a lowland area. Sandy, loamy and peat soils are characteristic for this area. Land use is dominated by agriculture and pasture. Drainage changed the natural water balance. In a nested approach we examined two catchment areas: a) Treene catchment 517 km 2 , b) Kielstau catchment 50 km 2 . The nested approach assists to improve the process understanding by using data of different scales. Therefore these catchments serve not only as an example but the results are transferable to other lowland catchment areas. In a first step the river basin scale model SWAT (Soil and Water Assessment Tool, Arnold et al., 1998) was used successfully to model the water balance. Furthermore the water quality was analysed to distinguish the impact of point and diffuse sources. The results show that the tributaries in the Kielstau catchment contribute high amounts of nutrients, mainly nitrate and ammonium. For the parameters nitrate, ammonium and phosphorus it was observed as a tendency that the annual loads were increasing along the river profile of the Kielstau.
The achievement of a good water quality in all water bodies until 2015 is legally regulated since December 2000 for all European Union member states by the European Water Framework Directive (EU, 2000). The aim of this project is to detect nutrient entry pathways and to assess the dominating hydrological processes in complex mesoscale catchments. The investigated Treene catchment is located in Northern Germany as a part of a lowland area. Sandy, loamy and peat soils are characteristic for this area. Land use is dominated by agriculture and pasture. Drainage changed the natural water balance. In a nested approach we examined two catchment areas: a) Treene catchment 517 km2, b) Kielstau catchment 50 km2. The nested approach assists to improve the process understanding by using data of different scales. Therefore these catchments serve not only as an example but the results are transferable to other lowland catchment areas. In a first step the river basin scale model SWAT (Soil and Water Assessment Tool, Arnold et al., 1998) was used successfully to model the water balance. Furthermore the water quality was analysed to distinguish the impact of point and diffuse sources. The results show that the tributaries in the Kielstau catchment contribute high amounts of nutrients, mainly nitrate and ammonium. For the parameters nitrate, ammonium and phosphorus it was observed as a tendency that the annual loads were increasing along the river profile of the Kielstau.
Co-fermentation of garden waste (GW) and food waste (FW) was assessed in a two-stage process coupling hyperthermophilic dark-fermentation and mesophilic anaerobic digestion (AD). In the first stage, biohydrogen production from individual substrates was tested at different volatile solids (VS) concentrations, using a pure culture of Caldicellulosiruptor saccharolyticus as inoculum. FW concentrations (in VS) above 2.9 g L-1 caused a lag phase of 5 days on biohydrogen production. No lag phase was observed for GW concentrations up to 25.6 g L-1. In the co-fermentation experiments, the highest hydrogen yield (46±1 L kg-1) was achieved for GW:FW 90:10% (w/w). In the second stage, a biomethane yield of 682±14 L kg-1 was obtained using the end-products of GW:FW 90:10% co-fermentation. The energy generation predictable from co-fermentation and AD of GW:FW 90:10% is 0.5 MJ kg-1 and 24.4 MJ kg-1, respectively, which represents an interesting alternative for valorisation of wastes produced locally in communities. ; This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER006684), Project SAICTPAC/0040/2015 (POCI-01-0145-FEDER016403) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020– Programa Operacional Regional do Norte. The authors also acknowledge the financial support of FCT and European Social Fund through the grant attributed to A.A. Abreu (SFRH/BPD/82000/2011). Research of A.J. Cavaleiro was supported by the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No 323009. ...
Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long- term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.